The 40 patients in the study were all diagnosed with early-stage breast cancer. Walker notes it is not surprising that chemotherapy drugs have bacteria-killing effects, since some are derived from antibiotics and all are metabolized through the liver and then the gut. He wondered whether chemotherapy might be unintentionally harming patients’ gut flora as well. This study on breast cancer patients was conceived after oncology professor John Mackey, former head of clinical trials at the Cross Cancer Institute, read a Scientific American article about the relationship between gut bacteria and obesity while on a plane trip home from a conference. “You are what you eat, subject to whatever the bacteria and enzymes in your body do to that food.” Unintended consequences of chemoĬhanges to the gut microbiota, known as dysbiosis, have been linked to chronic illnesses such as cardiovascular disease, Type 2 diabetes and obesity. “The old saying that ‘you are what you eat’ is just flat-out wrong,” adds co-investigator Gane Ka-Shu Wong, professor in the departments of medicine and biological sciences, who did molecular studies on gut bacteria and immune markers for the paper. There's something unique about this modulation of the gut microbiome for breast cancer patients who receive chemotherapy.” ”Our study shows there is a more nuanced explanation. “People tend to be a little less active during and after chemotherapy but they also tend to significantly reduce their caloric intake,” he says. Studies have shown that while 50 per cent of breast cancer patients are overweight or obese before their diagnosis, that rate goes up to 67 per cent after treatment.Ĭhanges to diet or exercise patterns during treatment are simply not significant enough to explain that difference, since they affect all patients who are treated for cancer, Walker notes. Many people lose weight after a cancer diagnosis, but that trend is reversed in breast cancer patients who undergo chemotherapy. Obesity has been linked with several kinds of cancer, including breast cancer, and oncologists have long observed that cancer treatment seems to make it worse. “Changes in the bacterial populations within the gut directly correlate with unhealthy weight gain and increased body fat composition in breast cancer patients who were treated with chemotherapy,” says lead author John Walker, associate professor in the Faculty of Medicine & Dentistry and head of medical oncology for northern Alberta at the Cross Cancer Institute.
The chemo patients also exhibited signs of inflammation and significant changes to the number and variety of bacteria in their guts. They found that the patients treated with chemotherapy lost muscle mass and gained abdominal fat, which has been linked to heart disease, diabetes and even cancer recurrence. In newly published research, a cross-disciplinary team at the University of Alberta tracked 40 early-stage breast cancer patients - half of whom received chemotherapy and half who were prescribed hormone treatment only. Beyond the front gates are plenty of opportunities for dining, shopping and recreation with The Domain and Domain NORTHSIDE just blocks away.Researchers have found a link between chemotherapy-induced changes to gut bacteria and the unhealthy weight gain seen in breast cancer patients, pointing the way to potentially help survivors avoid obesity-related illness later in their lives. This gated community also makes a great home for your pet with two on-site dog parks for you to enjoy. If you need to complete some work away from the distractions of home, you can take advantage of the business center with complimentary Wi-Fi. Stop by our redesigned twenty-four-hour fitness center, which comes complete with state-of-the-art equipment. The charming poolside sundecks also have access to grilling and picnic areas. Three resort-style swimming pools are available with sparkling depths and plenty of room for laps and relaxation.
Please schedule yours today.Tall trees and unique architecture give Folio a distinctive atmosphere. We are now accepting in-person and self-guided tours! Our virtual tours are also available. In addition to offering some of the best one, two and three bedroom North Austin apartments, the community at Folio is also your source for an unbeatable collection of resident amenities.
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